Stereoselective synthesis of 2-dienyl-substituted pyrrolidines using an eta4-dienetricarbonyliron complex as the stereodirecting element: Elaboration to the pyrrolizidine skeleton |
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| Authors: | Williams Iwan Kariuki Benson M Reeves Keith Cox Liam R |
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| Institution: | School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. |
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| Abstract: | Primary amines react with keto-aldehyde functionality located in the side-chain of an eta4-dienetricarbonyliron complex to provide the corresponding pyrrolidines in excellent diastereoselectivity. Two of the pyrrolidine products, 1i and 1k, have been elaborated into pyrrolizidines using a 1,5-C-H insertion and radical cyclization strategy, respectively. |
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