4-Hydroxy-2-quinolones. 44. Synthesis of 2-R-3-oxomorpholino[5,6-c]-6-R'-Quinolin-5-ones

Treatment of 1-R-2-oxo-4-hydroxyquinolin-3-ylamides of -halogen-substituted carboxylic acids with sodium methoxide leads to the formation of 2-R-3-oxomorpholino-5,6-c]-6-R-quinolin-5-ones. The antituberculosis activity of the compounds synthesized was studied.For Communication 43, see 1].National Pharmaceutical Academy of Ukraine, Kharkov 310002; e-mail: igor@uiv.kharkov.ua. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1080–1083, August, 2000.