Inhibitory study of two cephalosporins on <Emphasis Type="Italic">E. coli</Emphasis> by microcalorimetry |
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| Authors: | L N Yang Li Xian Sun Fen Xu J Zhang J N Zhao Z B Zhao C G Song R H Wu Riko Ozao |
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| Institution: | 1.Materials and Thermochemistry Laboratory, Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,People’s Republic of China;2.Department of Chemistry,Zunyi Normal College,Zunyi,People’s Republic of China;3.College of Chemistry and Chemical Engineering,Liaoning Normal University,Dalian,China;4.Division of Biotechnology, Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,People’s Republic of China;5.Dalian Institute of Drug Detection,Dalian,People’s Republic of China;6.Sony Corporation, Institute of Higher Education,Kanagawa,Japan |
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| Abstract: | The microcalorimetric method has been used to study the effects of cefpiramide and ceftizoxime sodium on the E. coli growth. The results revealed that these two cephalosporins may alter the metabolic way of the E. coli. Moreover, the lethal doses of cefpiramide and ceftizoxime sodium are 2.000 and 0.2000 μg mL−1, respectively. Combining with the relationships between growth rate constant (k), the maximum power output (P
m
), the time corresponding to the maximum power output (t
m
) and cephalosporins concentration (C), one can draw the conclusion that the ceftizoxime sodium has a stronger inhibition effects on the growth of E. coli than that of cefpiramide and they both have the possibility to induce the drug fever. |
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