Synthesis and properties of some pyrimido[5,4-d]pyrimidine derivatives |
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Authors: | N. E. Britikova A. S. Elina |
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Affiliation: | (1) S. Ordzhonikidze All-Union Scientific-Research Pharmaceutical-Chemistry Institute, 119021 Moscow |
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Abstract: | A method for the preparation of 2,4,8-trioxo-6-methyl derivatives of pyrimido[5,4-d]pyrimidine with various alkyl residues in the 7 position is described. It is shown that the chlorine in the 4 position of the 2,4-dichloro derivative of pyrimido[5,4-d]pyrimidine is the most labile in nucleophilic substitution reactions.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 4, pp. 517–520, April, 1977. |
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