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A highly efficient and direct approach for synthesis of enantiopure beta-amino alcohols by reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes
Authors:Zhong Yu-Wu  Dong Yi-Zhou  Fang Kai  Izumi Kenji  Xu Ming-Hua  Lin Guo-Qiang
Affiliation:Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences.
Abstract:A highly efficient and practical approach for the synthesis of optically pure beta-amino alcohols by the SmI2-induced reductive cross-coupling of chiral N-tert-butanesulfinyl imines with aldehydes was developed. This method allows the preparation of a broad range of chiral beta-amino alcohols, including functionalized ones under mild conditions. It provides a straightforward access to enantiopure beta-amino alcohols that are widely applicable in asymmetric synthesis.
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