2,3－二甲基－4－甲氧甲酰－2－环己烯醇的合成

2;3－二甲基－4－甲氧甲酰－2－环己烯醇的合成;二甲基甲氧甲酰环己烯醇;甲基甲氧甲酰环己烯酮;二甲基甲氧甲酰环己烯酮;氢化钠;氢化三叔丁氧基铝锂

Synthesis of 2,3-Dimethyl-4-carbomethoxy-2-cyclohexen-1-ol

Alkylation of methylcarbomethoxycyclohexenone 1 with iodomethane in a basic solution gave dimethylcarbomethoxycyclohexenone 2,which was transfered to dimethylcarbomethoxycyclohexenol 3 through the selective reduction of keto-carbonyl with a total yield of ca.60%.The effects of hydrogen-grabbing agents and reducing agent on the two reactions were studied.The results show that:the optimum hydrogen-grabbing agent and reducing agent for the alkylation and selective reduction of keto-carbonyl are sodium hydride and lithium-aluminum tri-tetra-butoxy hydride,and the yields of the alkylation and the reduction product are 90% and 67%,respectively.Their structures were confirmed by means of elemental analysis,UV-Vis,~(1)H NMR,IR,and MS spectra.