N-methyl-(R)-3-(tert-butyl)-sulfinyl-1,4-dihydropyridine: a novel NADH model compound |
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| Authors: | Xie Kun Liu You-Cheng Cui Yi Wang Jian-Ge Fu Yao Mak Thomas C W |
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| Institution: | Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China. wilma@mail.ustc.edu.cn |
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| Abstract: | We have synthesized a novel chiral NADH model compound, N-methyl-(R)-3-(tert-butyl)-sulphinyl-1,4-dihydropyridine with high enantioselectivity and used it in the reduction of methyl benzoylformate, producing (S)-methyl mandelate in 95% ee. The absolute structure of its precursor, 3-(tert-butyl)sulfinyl pyridine, was determined by X-ray analysis. |
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