| PPY／PVP催化剂合成11，2，4—三—0酰化红霉素的研究 |
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| 引用本文： | 魏荣宝,梁娅,何锋,姚方跃. PPY／PVP催化剂合成11，2，4—三—0酰化红霉素的研究[J]. 离子交换与吸附, 2001, 17(2): 165-168 |
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| 作者姓名： | 魏荣宝 梁娅 何锋 姚方跃 |
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| 作者单位： | 天津理工学院化工系, |
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| 摘 要： | 本文利用4－（1'－四氢吡咯）吡啶（PPY）及聚乙烯吡啶（PVP）复合催化剂催化合成了11,2',4'－三－0酰化红霉素衍生物,与传统方法相比,该法具有简单、快速、收率高等优点。一些影响素及反应机理被讨论,目标物收率为90％以上。
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| 关 键 词： | 红霉素 0－乙酰化反应 聚乙烯吡啶 4－（1‘－四氯吡咯）吡咯 复合催化剂 合成 抗菌药 |
| 文章编号： | 1001-5493(2000)02-0165-04 |
| 修稿时间： | 2000-04-06 |
STUDIES ON SYNTHESIS OF 11, 2', 4"-TRI-O-ACETYL ERYTHROMYCIN DERIVATIVE BY PPY/PVP AS CATALYST |
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| WEI Rongbao LIANG Ya HE feng YAO Fangyao Tianjin Institute of Technology,Tianjin. STUDIES ON SYNTHESIS OF 11, 2', 4"-TRI-O-ACETYL ERYTHROMYCIN DERIVATIVE BY PPY/PVP AS CATALYST[J]. Ion Exchange and Adsorption, 2001, 17(2): 165-168 |
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| Authors: | WEI Rongbao LIANG Ya HE feng YAO Fangyao Tianjin Institute of Technology Tianjin |
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| Affiliation: | WEI Rongbao LIANG Ya HE feng YAO Fangyao Tianjin Institute of Technology,Tianjin 300191 |
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| Abstract: | A new method to prepare 11, 2', 4"-tri-o-acetyl erythromycin derivative is finished by using 4-(1'-pyrrolidinyl) pyridine and Polyvinylpyridine as catalyst. Some effect parameters and reaction mechanism were discussed. The yield is above 90%. |
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| Keywords: | Erythromycin, 11,2',4" -tri-o-acetyl erythromycin derivative, Polyvinylpyridine, 4-(1'-pyrrolidinyl)pyridine. |
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