主链含酪氨酸的聚磷酸酯抗肿瘤药物的研究

通过含酪氨酸的聚磷酸酯与药物分子进行大分子反应，制备了含５－氟尿嘧啶或氨甲蝶呤的聚磷酸酯。所得聚磷酸酯均具有两亲性，部分聚磷酸酯在水中能形成胶束。研究了这些聚合物的体外降解和释药性能，体外抗肿瘤实验表明，有些聚磷酸酯药物具有较强的抗肿瘤活性。

Studies on the Tyrosine-Based Polyphosphate Antitumor Drugs

New polyphosphate antitumor durgs containing 5-Fu or MTX were synthesized by macromolecular reaction of polyphosphates with the corresponding drug molecules. All these polyphosphates obtained are amphiphilic, some of them have micelle-forming properties.The hydrolysis and in vitro drug release properties of these polyphosphates were studied.The in vitro antitumor activity data showed that some of these polyphosphates exhibit good antitumor activity.