Non-oral drug preparations containing cyclodextrin complexes |
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Authors: | L. Szente J. Szejtli M. Gál-Füzy |
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Affiliation: | 1. Biochemical Research Laboratory of Chinoin Pharm. Chem. Works Ltd., 1026 Endr?di S. u. 38/40, Budapest, Hungary
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Abstract: | The application of cyclodextrin complexed drugs in non-oral dosage forms results in the following advantages: - The stability of volatile, chemically unstable drugs is significantly improved by transforming them into cyclodextrin complexes. - The transformation of oils, liquids into crystalline, solid state provides better physical, mechanical properties, easy to handle products. - Complex formation/encapsulation on molecular scale/remarkably enhances the dissolution and absorption of lipophylic drugs. - The formation of water soluble inclusion complexes makes possible the preparation of parenteral dosage forms without using organic solvents or detergents. |
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