Synthesis of 2,5-bis(piperidinomethyl)piperidine and 1,5-bis(aminomethyl)-3-azabicyclo[3.2.1]octanones |
| |
| Authors: | E. M. Afsah M. A. Metwally M. M. Khalifa |
| |
| Affiliation: | 1. Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt
|
| |
| Abstract: | Schmidt reaction of mono- and bis-Mannich bases1 and2 c derived from cyclopentanone gave the corresponding basically substituted 2-piperidones3 and4, respectively. Reduction of the latter afforded5. DoubleMannich reaction of2 a–c with primary amines gave 3-azabicyclo[3.2.1]octanone derivatives6 a–e and7. The transamination of2 a was investigated. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
