Kit preparation of153Sm-EDTMP and factors affecting radiochemical purity and stability |
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| Authors: | G Ferro-Flores J I Tendilla M A López-Gómez M A González-Zavala L Parades-Gutiérrez E Avila-Ramírez F Aguilar-Hernández |
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| Institution: | (1) Department of Reactor and Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Km. 36.5 Carretera México-Toluca, C.P. 52045, Salazar, Edo. de México, (México);(2) Department of Nuclear Medicine, Instituto Nacional de Pediatría, Insurgentes 3700-C Colonia Cuicuilco Insurgentes, C.P. 04330, México, D.F., (México) |
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| Abstract: | A fast kit method was developed for the production of153Sm-EDTMP in two steps avoiding the use of nitric acid, evaporation and sterilization of the final solution by autoclave. Methods of analysis for the determination of chemical and radiochemical purity in the radiopharmaceutical solution were established. Factors affecting radiochemical purity and stability of the complex as the molar ratio of EDTMP/Sm, concentration of phosphate buffer and neutralization of EDTMP prior kit preparation were also analyzed. The use of this radiopharmaceutical in rabbits and patients showed selective skeletal uptake. |
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