Triazole-linked analogue of deoxyribonucleic acid ((TL)DNA): design, synthesis, and double-strand formation with natural DNA |
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| Authors: | Isobe Hiroyuki Fujino Tomoko Yamazaki Naomi Guillot-Nieckowski Marine Nakamura Eiichi |
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| Institution: | Department of Chemistry, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. isobe@mail.tains.tohoku.ac.jp |
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| Abstract: | A new triazole-linked analogue of DNA ((TL)DNA) has been designed and synthesized using click chemistry. The chain elongation reaction using copper-catalyzed Huisgen cycloaddition was successful and gave the artificial oligonucleotide that formed a stable double strand with the complementary strand of natural DNA. |
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