Gold nanoparticle induced conformational changes in heme protein |
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| Authors: | Dibakar Sahoo Prosenjit Bhattacharya Hirak Kumar Patra Paulami Mandal Sankar Chakravorti |
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| Institution: | (1) Department of Spectroscopy, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, 700032, India;(2) Department of Biochemistry, University of Calcutta, Kolkata, 700019, India;(3) Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden; |
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| Abstract: | Change of α-helical structure of heme protein (Hb) to a β-sheet and random coil conformation because of the interaction of
glycine capped gold nanoparticles (20–60 nm) as observed from attenuation total reflectance, absorption, Fourier transform
infra red, and Circular Dichroism spectroscopy has been reported in this article. Upon interaction, protein takes a cylindrical
shape of length 12 μm and diameter 0.35 μm as revealed from scanning electron microscopy and transmission electron microscopy.
The Selected-Area Electron beam Diffraction pattern shows change of crystalline structure in GNP to amorphous nature with
the interaction of Hb. |
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