Synthesis of dibenzo[def,p]chrysene, its active metabolites, and their 13C-labeled analogues |
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Authors: | Xu Daiwang Duan Yazhen Blair Ian A Penning Trevor M Harvey Ronald G |
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Institution: | Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. |
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Abstract: | Dibenzodef,p]chrysene (DBC) is a highly carcinogenic polycyclic aromatic hydrocarbon suspected to be involved in initiation of lung cancer in smokers. Efficient new syntheses of DBC, its active metabolites DBC diol (1), DBC dione (2), DBC diol epoxide (3)], and their previously unknown 13C2-labeled analogues are reported. The 13C2-labeled analogues are required as standards for sensitive methods of analysis of their DNA adducts in human cells using stable isotope dilution liquid chromatography/tandem mass spectrometry. |
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