4-Hydroxy-2-quinolones 140. Synthesis and diuretic activity of arylalkylamides of 4-methyl-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid |
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Authors: | I V Ukrainets N L Bereznyakova V A Parshikov V N Kravchenko |
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Institution: | (1) National University of Pharmacy, Kharkiv, 61002, Ukraine |
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Abstract: | The interaction of 4-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with thionyl chloride in oxygen-containing solvents
leads to the formation of a significant amount of colored side products, consequently it was proposed the reaction be carried
out in carbon tetrachloride. The synthesis of a series of amides was effected by the amidation of the obtained acid chloride
with appropriate primary arylalkylamines. Results are presented of a study of the effect of the synthesized compounds on the
urine-excreting function of the kidney.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 78–87, January, 2008. |
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Keywords: | amides 4-methyl-2-oxo-1 2-dihydroquinoline-3-carboxylic acid diuretic action X-ray structural analysis |
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