Trace detection of hormones and sulfonamides in viscous cosmetic products by neutral desorption extractive electrospray ionization tandem mass spectrometry |
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Authors: | Liu Yan Zhang Xinglei Ouyang Yongzhong Hu Zhong Ma Li Zhang Jinghua Lin Jinming Chen Huanwen |
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Institution: | Beijing Center for Physical and Chemical Analysis, Beijing 100089, PR China. |
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Abstract: | A sensitive method based on a geometry-independent neutral desorption (GIND) in combination with extractive electrospray ionization mass spectrometry (EESI-MS) has been developed for fast detection of illicit additives such as sulfonamides and hormones in highly viscous cosmetic products. The method gave a low limit of detection (LOD) (in the range of 0.001-1 ng/g), acceptable relative standard deviation (RSD=6.8-11.4%) and reasonable recovery (87-116%) for direct measuring of nine types of hormones and sulfonamides in the cosmetic products. The average measurement time for two types of samples was less than 1 min. Trace amounts of analytes in commercial cosmetic products have been quantitatively detected, without any sample pretreatment. The experimental results showed that non-volatile illicit additives such as sulfonamides and hormones could be sensitively liberated using the GIND device for quantitative detection from the highly viscous cosmetic products, demonstrating that GIND-EESI-MS is a promising tool for high throughput, sensitive and quantitative analysis of highly complex viscous samples. |
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Keywords: | ND EESI viscous samples cosmetic products hormones sulfonamides quantitative detection high throughput analysis |
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