|
|||||
|
|
Liposome delivered and polymeric metal complexes as potential sensitizers for the photodynamic therapy of cancer |
|
| Authors: | Dieter Wöhrle Maria Shopova Jörg G Moser Holger Kliesch Ulrike Michelsen Silke Müller Andrea Weitemeyer |
| Institution: | 1. Institut für Organische und Makromolekulare Chemie, Universität Bremen, NW 2, P.O. Box 330 440, 28334 Bremen;2. Bulgarian Academy of Sciences, Institute of Organic Chemistry, 1113 Sofia, Bulgaria;3. Institut für Lasermedizin, Universität Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany |
| Abstract: | Different possibilities of macromolecular metal complexes as photosensitizers (PS) for their potential use in the photodynamic therapy of cancer are described. The prepared metal porphyrazin derivatives (metals: Zn(II), Si(IV)(X)2) exhibit long wavelength absorption and high singlet oxygen quantum yields under irradiation. One possibility is the incorporation of the PSs in liposomal vesicles giving hydrophobic conjugates with low densitiy proteins in the serum after injection. Good tumor accumulation and photodynamic activities are observed. Increased tumor uptake is also known for Pcs covalently connected via the ligand to poly(ethylene glycol monomethyl ether). New compounds contain the hydrophilic polymer at axial substituents of Si(X)2Pc and Si(X)2Nc. Some newly synthesized compounds with only one functional group exhibit the possibility of coupling to macromolecules like e.g. monoclonal antibodies. |
| Keywords: | |