Aroylation of 5-amino-2H-1,2,4-thiadiazolin-3-one |
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Authors: | Nam Sook Cho Chan Soo Ra Do Young Ra Jin Soo Song Sung Kwon Kang |
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Abstract: | 2-Aroyl-5-aroylamino-1,2,4-thiadiazolin-3-ones 2 have been synthesized through aroylation of 5-amino-2H-1,2,4-thiadiazolin-3-one ( 1 ) as an analog of cytosine. The aroylation was carried out with a substituted aroyl chloride in pyridine at 56–58°. It has been established that the intermediates of the reactions are 2-aroyl-5-amino-1,2,4-thiadiazolin-3-ones 3 on the basis of the spectral data, additional experimental information and ab initio molecular orbital calculations. |
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