Controlled polymerization of ϵ-caprolactone -from macromolecules to microspheres |
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Authors: | Stanislaw Slomkowski |
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Abstract: | Pseudoanionic polymerization of ϵ-caprolactone (CL), initiated with dialkylaluminum alkoxides, was used for the tailored synthesis of poly(CL) with M̄n ≤ 100 000 and M̄w /M̄n < 1. 20. Macromolecules with functional groups at one or at both ends were obtained in this way. Controlled polymerization of CL allowed to prepare poly(dodecyl acrylate)-g-poly(ϵ-caprolactone) (poly(DAC)-g-poly(CL)) with well defined poly(CL) grafts. These copolymers were used as the surface active agents for the direct synthesis of poly(CL) microspheres. The number average diameter (D̄n ) of poly(CL) microspheres varied from 0.628 μm to 0.94 μm and the diameter polydispersity (D̄v /D̄n ) varied from 1.038 to 1.26, depending on the composition of poly(DAC)-g-poly(CL). Human serum albumin (HSA) and human gamma globulins (γ G) were attached to the poly(CL) microspheres. The maximal surface concentrations of HSA and γ G adsorbed onto the microspheres were equal to 9·10−4 g/m2 and 2.0·10−3 g/m2 respectively. |
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