Synthesis of 9-[(2-hydroxy-1-phosphonylethoxy)ethyl]guanine, 1-[(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine and 9-[(2-hydroxy-1-phosphonylethoxy)ethyl] adenine |
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Authors: | Dae-Kee Kim Jongsik Gam Key H Kim |
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Abstract: | The acyclic nucleoside phosphonate analogues, 9-(2-hydroxy-1-phosphonylethoxy)ethyl]guanine 6 , 1-(2-hydroxy-1-phosphonylethoxy)ethyl]cytosine 7 and 9-(2-hydroxy-1-phosphonylethoxy)ethyl]adenine 8 , have been prepared by the coupling of a tosylate of the phosphonate side chain 12 with a purine or pyrimidine base followed by deprotection of the blocking groups. |
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