| Abstract: | The sorption of the plasma proteins human serum albumin (HSA) and human fibrinogen (FIB) onto hemodialytic cellulosic substrates was investigated by the surface sensitive ATR-FTIR-spectroscopy. By means of this method we monitored the protein sorption kinetics onto acetylated and unmodified cellulose (AKZO-NOBEL). Furthermore, secondary structure alterations of the adsorbed proteins as well as changes of the composition in sorbed layers consisting of two proteins were detected. These findings were compared with results of the zeta potential and contact angle measurements on comparable sorption experiments. |
