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High performance fourier transform ion cyclotron resonance mass spectrometric detection for capillary electrophoresis
Authors:Steven A Hofstadler  Joanne C Severs  Richard D Smith  Frank D Swanek  Andrew G Ewing
Abstract:We describe the current state of the on-line combination of capillary electrophoresis (CE) electrospray ionization (ESI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS), and discuss aspects of the FTICR technique relevant to its use as a detection scheme for on-line separations. Aspects including sensitivity, mass resolution, duty cycle, and tandem mass spectrometric capabilities are discussed in the context of online separations with examples from the authors' laboratory.
Keywords:Capillary electrophoresis  Mass spectrometry  Electrospray ionization  Fourier transform ion cyclotron  Resonance  Biomolecule analysis
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