Liquid chromatographic optimization of reaction conditions for the synthesis of 2,2-dimethyl-N-benzylmalonamide, a new anticonvulsant |
| |
Authors: | C L McMillian J DeRuiter C R Clark |
| |
Institution: | Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Alabama 36849. |
| |
Abstract: | Reversed-phase liquid chromatographic (RP/LC) procedures are used to optimize the reaction conditions for the large scale preparation of 2,2-dimethyl-N-benzylmalonamide, 1. In acute studies using mice and rats, compound 1 is a very effective anticonvulsant agent. Large quantities of 1 (ca. 300 g) are needed for detailed studies of its chronic effects. LC monitoring of the synthesis of intermediate products and 1 result in the optimum use of reagents, increased product yields, and decreased reaction times. |
| |
Keywords: | |
|
|