以分子印迹电聚合膜为仿生受体检测辛可宁

结合分子印迹技术和电聚合自组装技术制备了以辛可宁为模板的印迹聚合膜．膜的厚度可通过改变扫描次数和速度加以控制，因此可在一定程度上克服传统印迹材料固有的传质较慢等缺点．实验中采用铁氰化钾作为探针分子．当模板分子被洗脱后，铁氰化钾小分子可以自由通过聚合膜所形成的识别孔穴，并在电极表面发生氧化还原反应．当识别孔穴捕获辛可宁分子后，

Detection of Cinchonine Using Molecularly Imprinted Electrosynthesized Polymer as Biomimetic Receptor Layers

An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol(o-AT) to prepare imprinted film using cinchonine as the model template analyte. The procedure of forming recognition cavity and the effect of the ratio of monomers to templates on the imprinted film, together with sensitivity and selectivity to cinchonine on the imprinted electrode, were demonstrated. An indirect and rapid detection was carried out using potassium ferricyande as a probe. Stable response is achieved within 4 min, covering a linear range (5.0×10^-6)₄.0×10^-5 mol/L. From the results, the main driving force for recognition is supposed to be hydrophobic interaction, complementary cavity effect and phenyl group for π-π interactions with the enaphthyl residue.