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Dynamics of morphological changes for mitochondrial fission and fusion
Authors:WANG ShiQi       FU ChangLiang   ZHANG Yan   CHEN Quan & LONG Mian    Key Laboratory of Microgravity   Beijing   China   Center for Biomechanics    Bioengineering
Affiliation:National Microgravity Laboratory
Abstract:Mitochondria experience continuous fusion and fission in a living cell, but their dynamics remains poorly quantified. Here a theoretical model was developed, upon a simplified population balance equation (PBE), to predict the morphological changes induced by mitochondrial fission and fusion. Assuming that both fission and fusion events are statistically independent, the survival probability of mitochondria staying in the fission or fusion state was formulated as an exponentially-decayed function with time, ...
Keywords:mitochondria  morphology  fission  fusion  dynamics  modeling  
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