Ion trap tandem mass spectrometric determination of F2-isoprostanes |
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| Authors: | Signorini Cinzia Comporti Mario Giorgi Gianluca |
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| Affiliation: | Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Via Aldo Moro, 53100 Siena, Italy. |
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| Abstract: | A new tandem mass spectrometry (MS/MS) method based on the use of an ion trap mass spectrometer for the identification and quantitation of F(2)-isoprostanes has been developed. It consists of two solid-phase extractions and two derivation steps followed by gas chromatography/negative ion chemical ionization tandem mass spectrometry (GC/NICI-MS/MS) analysis. This method is highly selective and sensitive and it has been successfully applied to biological samples. |
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| Keywords: | ion trap tandem mass spectrometry isoprostanes |
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