1. Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA;2. Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA;3. The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Abstract:
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Highlights? Populations of replicating RNAs were constructed by encoded combinatorial chemistry ? The RNAs evolve based on a heritable genotype and corresponding catalytic phenotype ? Genotype and phenotype are related by a user-specified genetic code ? The evolved enzymes included both highly active catalysts and molecular parasites
