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Design and synthesis of novel fused heterocycles using 4-chromanone as synthon |
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| Authors: | Ali K. A. Abdelhafez N. A. A. Ragab E. A. Ibrahim A. A. Amr A. E. |
| Affiliation: | 1.Applied Organic Chemistry Department, National Research Centre, Dokki, Giza, 12622, Egypt ;2.Chemistry Department, Faculty of Science, Cairo University, Giza, Egypt ;3.Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh, 11451, Saudi Arabia ; |
| Abstract: | A new series of heterocyclic systems, including azole, azolopyrimidine, and pyridopyrimidine derivatives, attached to 2H-chromene scaffold, was prepared by a convenient procedure through the reactions of (E)-2-dimethylamino-methylene chromanone with different nitrogen binucleophiles. Various substituted chromeno[4,3-b]pyridine derivatives were also prepared through the reactions of (E)-2-dimethylaminomethylene chromanone with a series of active methylene compounds. |
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