Codon Randomization for Rapid Exploration of Chemical Space in Thiopeptide Antibiotic Variants期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Codon Randomization for Rapid Exploration of Chemical Space in Thiopeptide Antibiotic Variants

Authors:	Travis S Young Pieter C Dorrestein Christopher T Walsh

Institution:	1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Armenise 608, Boston, MA 02115, USA;2. Skaggs School of Pharmacy and Pharmaceutical Sciences, Departments of Pharmacology and Chemistry and Biology, University California, San Diego, 9500 Gilman Drive, MC 0636, La Jolla, CA 92093-0636, USA

Abstract:	Download : Download high-res image (261KB) Download : Download full-size image Highlights? Thiopeptide GE37468 expression was increased 30-fold above previous reports ? Codon randomization enabled rapid exploration of chemical space ? Thirteen thiopeptide analogs had activity against MRSA ? Identification of linear precursor peptides allowed insights into biosynthetic timing

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