Incorporation of a molecular hinge into molecular tweezers by using tandem cycloadditions onto 5,6-dimethylenenorbornene |
| |
Authors: | Warrener R N Butler D N Liu L Margetic D Russell R A |
| |
Institution: | Centre for Molecular Architecture, Central Queensland University, Australia. r.warrener@cqu.edu.au |
| |
Abstract: | Site-selective 1,3-dipolar coupling at the norbornene pi-bond of 5,6-dimethylenenorbornene 1 yields cycloadducts with an end-fused 1,3-diene system which have been reacted with N=N (or C=C) dienophiles to produce ribbon molecules, in which the internal diazacyclohexene (or cyclohexene) subunits are capable of acting as conformational hinges. Direct coupling of 5,6-dimethylenenorbornene with 1,3,4-oxadiazoles or dual coupling with bis(cyclobutene epoxides) afforded bis(1,3-dienes) that diastereoselectively react with dienophiles to produce new, conformationally mobile, molecular tweezers. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|