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A novel chiral phosphinediamine ligand and asymmetric hydrogenation of acrylic acid derivatives |
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| Authors: | Issaku Yamada Motowo Yamaguchi Takamichi Yamagishi |
| Institution: | Department of Industrial Chemistry, Faculty of Engineering, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo 192-03, Japan |
| Abstract: | A novel chiral phosphinediamine ligand (PN2) was prepared from (S)-1-phenylethylamine and dichloroisopropylphosphine. The rhodium-PN2 catalyst utilizing selective ligation of the amino unit and electrostatic interaction between the ligand and a substrate gave high enantioselectivities up to 92% ee in asymmetric hydrogenations of acrylic acid derivatives. |
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