Functionalized porous silica microspheres as scavengers in parallel synthesis |
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Authors: | Thompsona L A Combsa A P Trainor G L Wangb Q Langloisb T J Kirkland J J |
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Institution: | DuPont Pharmaceuticals Company, Experimental Station, Wilmington, DE 19880-0500, USA. drew.a.thompson@dupontpharma.com |
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Abstract: | The use of solid scavengers in parallel solution-phase organic synthesis is an effective method for work-up and purification. Functionalized macroreticular or gel-form polystyrene particles are generally used for scavenging applications, how ever these materials have some limitations. We have developed new scavenging reagents based on ultrapure silica microspheres displaying a variety of functional groups useful for sequestering impurities from reaction products. These materials are easy to handle, have excellent mass-transfer properties, and are efficient scavengers in both polar and nonpolar organic solvents. The properties of these materials were tailored specifically to fit the needs of a medicinal chemist employing parallel synthesis techniques in current commercial equipment. Results are presented from head-to-head comparisons with conventional scavengers in tests designed to demonstrate the versatility of these new materials. |
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