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Zirconium phosphate nano-platelets: a novel platform for drug delivery in cancer therapy |
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| Authors: | Díaz Agustín Saxena Vipin González Julissa David Amanda Casañas Barbara Carpenter Carrie Batteas James D Colón Jorge L Clearfield Abraham Hussain M Delwar |
| Institution: | Department of Chemistry, Texas A&M University, PO Box 30012, College Station, TX 77842-3012, USA. diaz@chem.tamu.edu |
| Abstract: | Doxorubicin was intercalated into novel zirconium phosphate nano-platelets (ZrP). The obtained doxorubicin intercalated ZrP nano-platelets had an impressive 34.9% (w/w) drug loading. We used this material to deliver doxorubicin to breast cancer cells (MCF-7). Cellular studies with MCF-7 cells showed higher uptake and cytotoxicity of doxorubicin loaded ZrP compared to free doxorubicin. |
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