| Preparation of Formyl Deoxycholic Acid Modified Fe3O4 Nanoparticles and Their Application for Oxytetracycline Loading北大核心CSCD |
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| 引用本文： | 弓韬,文朝朝,秦凯莉,赵莹珠,张宇奇,梁文婷,董川.Preparation of Formyl Deoxycholic Acid Modified Fe3O4 Nanoparticles and Their Application for Oxytetracycline Loading北大核心CSCD[J].应用化学,2022,39(12):1920-1926. |
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| 作者姓名： | 弓韬 文朝朝 秦凯莉 赵莹珠 张宇奇 梁文婷 董川 |
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| 作者单位： | 1.山西医科大学基础医学院，太原 030001;2.山西大学环境科学研究所，太原 030006 |
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| 基金项目： | 国家自然科学基金(21976113);山西省自然科学基金(202103021224240) |
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| 摘 要： | Formyldeoxycholic acid modified Fe3O4 nanoparticles（FDCA-MNPs）have been successfully constructed. The structure，morphology and magnetic properties of FDCA-MNPs are characterized by Fourier transform infrared spectroscopy（FT-IR），transmission electron microscopy（TEM）and vibrating sample magnetometer. Oxytetracycline（OTC）is used as a model drug to evaluate the drug loading and release behaviors of FDCA-MNPs. The maximum loading of OTC is 59. 7 mg/g，and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption．Furthermore，FDCA-MNPs@OTC shows a higher release rate at pH=9 （11. 8%）than that of pH=7（8. 8%）. The bacteriostatic activities of FDCA-MNPs，OTC，FDCA-MNPs@OTC against E. coli are compared in vitro. The results show that FDCA-MNPs have no inhibition-activity for E. coli， meanwhile，FDCA-MNPs@OTC displays better sterilization ability than OTC at the same concentration. The minimum antibacterial concentration is 3 μg/mL，and the antibacterial rate reaches 97. 8%. It is proved that the synergistic effect of drug carrier and drugs reveals good antibacterial properties and reduce the dosage of antibiotics. © 2022, Science Press (China). All rights reserved.
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| 关 键 词： | Fe3O4纳米粒子 土霉素 药物释放 |
| 收稿时间： | 2022-04-22 |
Preparation of Formyl Deoxycholic Acid Modified Fe3O4 Nanoparticles and Their Application for Oxytetracycline Loading |
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| Tao GONG,Chao-Chao WEN,Kai-Li QIN,Ying-Zhu ZAHO,Yu-Qi ZHANG,Wen-Ting LIANG,Chuan DONG.Preparation of Formyl Deoxycholic Acid Modified Fe3O4 Nanoparticles and Their Application for Oxytetracycline Loading[J].Chinese Journal of Applied Chemistry,2022,39(12):1920-1926. |
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| Authors: | Tao GONG Chao-Chao WEN Kai-Li QIN Ying-Zhu ZAHO Yu-Qi ZHANG Wen-Ting LIANG Chuan DONG |
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| Institution: | 1.Department of Biochemistry and Molecular Biology，Shanxi Medical University，Taiyuan 030001，China;2.Institute of Environmental Science，Shanxi University，Taiyuan 030006，China |
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| Abstract: | Formyldeoxycholic acid modified Fe3O4 nanoparticles （FDCA-MNPs） have been successfully constructed. The structure， morphology and magnetic properties of FDCA-MNPs are characterized by Fourier transform infrared spectroscopy （FT-IR）， transmission electron microscopy （TEM） and vibrating sample magnetometer. Oxytetracycline （OTC） is used as a model drug to evaluate the drug loading and release behaviors of FDCA-MNPs. The maximum loading of OTC is 59.7 mg/g， and the loading behavior follows Freundlich adsorption balance equations with multilayer adsorption．Furthermore， FDCA-MNPs@OTC shows a higher release rate at pH=9 （11.8%） than that of pH=7 （8.8%）. The bacteriostatic activities of FDCA-MNPs， OTC， FDCA-MNPs@OTC against E.coli are compared in vitro. The results show that FDCA-MNPs have no inhibition-activity for E.coli， meanwhile， FDCA-MNPs@OTC displays better sterilization ability than OTC at the same concentration. The minimum antibacterial concentration is 3 μg/mL， and the antibacterial rate reaches 97.8%. It is proved that the synergistic effect of drug carrier and drugs reveals good antibacterial properties and reduce the dosage of antibiotics. |
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| Keywords: | Fe3O4 nanoparticles Terramycin Drug release |
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