Synthesis of <Emphasis Type="Italic">N</Emphasis>-Arylsulfonyl-α-thienylglycines from <Emphasis Type="Italic">N</Emphasis>-(2,2,2-Trichloro-1-thienylethyl)arenesulfonamides

Reactions of N-(2,2,2-trichloroethylidene)arenesulfonamides with thiophene, 2-chlorothiophene, and 2,5-dichlorothiophene, as well as of N-(2,2,2-trichloro-1-hydroxyethyl)arenesulfonamides with 2-chlorothiophene, lead to formation of the corresponding N-(2,2,2-trichloro-1-thienylethyl)arenesulfonamides. Alkaline hydrolysis of the latter occurs selectively at the trichloromethyl group to give N-arylsulfonyl-α-thienylglycines.__________Translated from Zhurnal Organicheskoi Khimii, Vol. 41, No. 1, 2005, pp. 93–96.Original Russian Text Copyright © 2005 by Aizina, Rozentsveig, Ushakova, Levkovskaya, Mirskova.