Non-protein amino acids in peptide design |
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| Authors: | S Aravinda N Shamala Rituparna S Roy and P Balaram |
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| Institution: | (1) Department of Physics, Indian Institute of Science, 560 012 Bangalore, India;(2) Molecular Biophysics Unit, Indian Institute of Science, 560 012 Bangalore, India;(3) Chemical Biology Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur Campus, Jakkur PO, 560 064 Bangalore, India |
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| Abstract: | An overview of the use of non-protein amino acids in the design of conformationally well-defined peptides, based on work from
the author’s laboratory, is discussed. The crystal structures of several designed oligopeptides illustrate the useα-aminoisobutyric acid (Aib) in the construction of helices, D-amino acids in the design of helix termination segments andDPro-Xxx segments for nucleating ofβ-hairpin structures.β- andγ-amino acid residues have been used to expand the range of designed polypeptide structures.
Dedicated to Professor C N R Rao on his 70th birthday |
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| Keywords: | Peptide design crystal structures C-H… O hydrogen bond hybrid peptides D-amino acids β -amino acids |
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