The mono-alkyldecyanation of tetrafluoroterephthalonitrile by reaction with Grignard reagents期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The mono-alkyldecyanation of tetrafluoroterephthalonitrile by reaction with Grignard reagents

Institution:	1. Institute of Traditional Chinese Medicine and Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, People''s Republic of China;2. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of Pharmacy, Jinan University, Guangzhou 510632, People''s Republic of China;3. Key Laboratory of Standard Material in Natural Medicine of Guangdong Province, Guangzhou Xiangxue Pharmaceutical Ltd. Co., Guangzhou 510663, China

Abstract:	Treatment of tetrafluoroterephthalonitrile in THF with alkyl Grignard reagents gives the corresponding 4-alkyltetrafluorobenzonitrile in about 60% yield. The scope and limitations of this transformation are reported.

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