Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas |
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| Authors: | Yi-Lin He Pei-Zhi Huang Hong-Ying Yang Wei-Jiao Feng Zhao-Cai Li Kun Gao |
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| Affiliation: | 1.State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China; (Y.-L.H.); (P.-Z.H.); (H.-Y.Y.); (W.-J.F.);2.Research Institute, School of Biological and Pharmaceutical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China;3.State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; |
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| Abstract: | Two new neolignans jatrolignans, C (1) and D (2), a pair of epimers, were isolated from the whole plants of Jatropha curcas L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in Chlamydia abortus. They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM. |
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| Keywords: | Euphorbiaceae Jatropha curcas L. neolignan jatrolignans epimers antichlamydial activity |
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