An overview of lipid membrane supported by colloidal particles |
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Authors: | Troutier Anne-Lise Ladavière Catherine |
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Affiliation: | Laboratoire des Matériaux Inorganiques, UMR 6002-CNRS, Université Blaise Pascal, 24 avenue des Landais, 63177 Aubière Cedex, France. |
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Abstract: | In recent years, original hybrid assemblies composed of a particle core surrounded by a lipid shell emerged as promising entities for various biotechnological applications. Their broadened bio-potentialities, ranging from model membrane systems or biomolecule screening supports, to substance delivery reservoirs or therapeutic vectors, are furthered by their versatility of composition due to the possible wide variation in the particle nature and size, as well as in the lipid formulation. The synthesis, the characteristics, and the uses of these Lipid/Particle assemblies encountered in the literature so far are reviewed, and classified according to the spherical core size in order to highlight general trends. Moreover, several criteria are particularly discussed: i) the interactions involved between the particles and the lipids, and implicitly the assembly elaboration mechanism, ii) the most suited techniques for an accurate characterization of the entities from structural and physicochemical points of view, and iii) the remarkable properties of the solid-supported lipid membrane obtained. |
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Keywords: | AFM, atomic force microscopy AMA, methacrylic acid 6-CF, 6-carboxyfluorescein CSLM, confocal scanning laser microscopy Di6ASP-BS, N-(3-sulfopropyl)-4-(4-(didecylamino) styryl) pyridinium DiIC16(3), 1,1′-dihexadecyl-3,3,3′,3′-tetramethyl indocarbocyanine perchlorate DPH, 1,6-diphenyl-1,3,5-hexatriene DSC, differential scanning calorimetry ELISA, enzyme linked immuno sorbent assay FRAP, fluorescent recovery after photo-bleaching FRET, fluorescent resonant energy transfer IgE, immunoglobulin E MBMA, methylene bis acrylamide MBP, myelin basic protein NBD, [(7-nitro-2-1,3-benzoxadiazol-4-yl)amino] NMR, nuclear magnetic resonance PAH, poly(allylamine hydrochloride) PEG, poly(ethylene glycol) PSS, poly(styrene sulfonate) PVA, poly(vinyl alcohol) RNA, ribonucleic acid SMBV, SupraMolecular BioVector™ SSV, spherical supported vesicles TEM, transmission electron microscopy Tm, lipid phase transition temperature XPS, X-ray photoelectron spectroscopy Lipid head groups:PA, phosphatidic acid PC, phosphatidylcholine PE, phosphatidylethanolamine PG, phosphatidylglycerol PS, phosphatidylserine TAP, trimethylammonium propane Lipid chain lengths:DM, dimyristoyl C14:0 DO, dioleoyl C18:1 DP, dipalmitoyl C16:0 DS, distearoyl C18:0 PO, palmitoyl-oleoyl C16:0-C18:0 Other lipids:DHDAB, dihexadecyldimethylammonium bromide DODAB, dioleoyldimethylammonium bromide DODAC, dioleoyldimethylammonium chloride. |
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