Synthesis and biological evaluation of nucleoside dicarboxylates as potential mimics of nucleoside diphosphates |
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| Authors: | Boudreau Marc A Vederas John C |
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| Institution: | Department of Chemistry, Gunning/Lemieux Chemistry Centre, University of Alberta, Edmonton, Alberta T6G 2G2, Canada. |
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| Abstract: | A series of nucleotide analogues wherein the diphosphate moiety has been replaced by a dicarboxylate were synthesized and tested for inhibitory activity against nucleoside diphosphate (NDP) kinase as well as several pathogenic bacterial strains. |
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