Electroanalysis of Benazepril Hydrochloride Antihypertensive Drug Using an Ionic Liquid Crystal Modified Carbon Paste Electrode |
| |
| Authors: | Ahmed Galal Nada F. Atta Shereen M. Azab Asmaa H. Ibrahim |
| |
| Affiliation: | 1. Department of Chemistry, Faculty of Science, Cairo University, 12613 Giza, Egypt tel: +20?02?35676561;2. fax: +20?02?35727556;3. National Organization for Drug Control and Research (NODCAR), Giza, Egypt |
| |
| Abstract: | Electroanalysis of benazepril HCl was successful using a carbon paste electrode modified with an ionic liquid crystal ( 1‐butyl‐1‐methylpiperidinium hexafluorophosphate) in presence of sodium dodecyl sulfate. The electrode performance was compared to ionic liquids (1‐n‐hexyl‐3‐methyl imidazolium tetrafluoroborate and 1‐butyl‐4‐methyl pyridinium tetrafluoroborate). Electrochemical determination of benazepril HCl was in the linear dynamic range of 8.89×10?7 to 1.77×10?5 mol L?1 (correlation coefficient 0.999) and LOD 7.17×10?9 mol L?1. benazepril HCl was determined using this sensor in presence of urine metabolites such as uric acid, ascorbic acid. Binary mixtures of dopamine/benazepril and amlodipine/benazepril were also determined successfully. |
| |
| Keywords: | Ionic liquid crystal Electroanalysis Benazepril HCl Surfactants Carbon paste electrode |
|
