Green and Straightforward Modification of Graphite Electrode via In Situ Synthesis of Graphene Nanosheets for Quantifying Prazosin Hydrochloride in Urine Samples and Pharmaceutical Formulations |
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| Authors: | Sasan Rabieh Ashkan Koushanpour Fariba Tajabadi |
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| Institution: | 1. Applied Chemistry Department, Chemistry Faculty, Shahid Beheshti University, Evin, Tehran, Iran;2. Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran |
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| Abstract: | A sensitive electrochemical sensor based on in situ modification of graphite electrode via graphene nanosheets (GNs) was developed as a green method for prazosin hydrochloride (PRA) analyses. In this study, GNs were electrochemically synthesized on the surface of graphite electrode via in situ approach and used for the analyses. The proposed sensor showed several advantages such as high sensitivity, low LOD, and excellent repeatability. The oxidation peak current at the optimum analytical conditions using a GNs/graphite electrode at pH 6.0 was linearly dependent on PRA concentration in the range of 0.09–100 µM. A LOD of 0.02 µM and RSD of 3.8 % for 10 µM solution of PRA with a great recovery were obtained. |
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| Keywords: | Differential pulse voltammetry Graphene nanosheets Green approach In situ synthesis Prazosin hydrochloride |
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