Synthesis of pyrazine-phosphonates and -phosphine oxides from 2H-azirines or oximes |
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Authors: | Palacios Francisco Ochoa de Retana Ana María Gil José Ignacio López de Munain Rafael |
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Institution: | Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain. qoppagaf@vc.ehu.es |
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Abstract: | reaction: see text] Tetrasubstituted pyrazines containing two phosphonate groups 2 in positions 2 and 5 and trisubstituted pyrazines containing a phosphonate 5 or a phosphine oxide group 7 in position 2 are obtained by thermal treatment of 2H-azirine-2-phosphonates 1 and -phosphine oxides 6. These pyrazines can also be prepared from beta-ketoxime tosylates 9 and 10 or from oxime derived from phosphine oxide 11. |
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