A facile approach to the synthesis of chiral 2-substituted benzofurans |
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Authors: | De Luca Lidia Giacomelli Giampaolo Nieddu Giammario |
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Affiliation: | Dipartimento di Chimica, Università degli Studi di Sassari, via Vienna 2, I-07100 Sassari, Italy. |
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Abstract: | An effective route to chiral optically active 2-substituted benzofurans directly from carboxylic acids is reported. This procedure, which allows the preparation of alpha-alkyl-2-benzofuranmethanamines from N-protected alpha-amino acids without sensible racemization phenomena, proceeds in good yields under mild conditions with the help of microwave irradiation. |
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