A new synthetic route to aminothiazolinones |
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Authors: | M Kidwai A D Mishra |
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Institution: | (1) Department of Chemistry, University of Delhi, Delhi-, 110007, India |
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Abstract: | Novel 2-(5-R-1,3,4-thiadiazol-2-yl)aminothiazolin-4-ones 6a—h and 2-imino-3-(5-R-1,3,4-thiadiazol-2-yl)thiazolidin-4-ones 7a—h were prepared by treating N-(5-R-1,3,4-thiadiazol-2-yl)thioureas 4a—h with chloroacetic acid on various solid supports under microwave irradiation. Tautomeric mixtures of compounds 6a—h and 7a—h were obtained in all cases. In alkaline and neutral media, compounds 6a—h were the major products, while in acid media, 7a—h were the major products. |
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Keywords: | aminothiazolinones iminothiazolidinones thiadiazoles thioureas tautomers solid supports |
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