Intramolecular Cyclization Strategies Toward the Synthesis of Zoanthamine Alkaloids |
| |
| Authors: | Fischer Derek Nguyen Thong X Trzoss Lynnie Dakanali Marianna Theodorakis Emmanuel A |
| |
| Institution: | Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA |
| |
| Abstract: | Stabilized 2-amino-1,3-dienes can participate in intramolecular Diels-Alder (IMDA) reactions with pendant dienophiles. We found that these dienes can be readily prepared via standard palladium-mediated coupling reactions and have comparable reactivity to 2-oxodienes. Application of these substrates to the synthesis of tetracyclic model systems representing the ABCE motif of the zoanthamines is presented. |
| |
| Keywords: | Zoanthamine Cycloaddition Aminodiene Stille coupling Diels-Alder reaction |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
