Tricyclic thiazolo[3,2-a]thiapyrano[4,3-d]pyrimidines and related analogs as potential anti-inflammatory agents |
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Authors: | George Rovnyak Virginia Shu Joseph Schwartz |
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Abstract: | A series of novel tricyclic thiazolo[3,2-a]thiapyrano[4,3-d]pyrimidines and related oxa, aza and carbo analogs of general formula 1 were prepared by a convenient addition-cyclization reaction involving 2-amino-2-thiazoline ( 4 ) and bisarylidene ketones of formula 3. Some of these compounds demonstrated antiinflammatory activity. |
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