Nitroxyl radicals: electrochemical redox behaviour and structure-activity relationships |
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| Authors: | Manda Sushma Nakanishi Ikuo Ohkubo Kei Yakumaru Haruko Matsumoto Ken-ichiro Ozawa Toshihiko Ikota Nobuo Fukuzumi Shunichi Anzai Kazunori |
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| Institution: | Radiation Modifier Team, Heavy-Ion Radiobiology Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Inage-ku, Chiba 263-8555, Japan. |
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| Abstract: | Comparative study of electrochemical redox behaviour of five different nitroxyl radicals leads to the direct correlation between one-electron redox potentials and group electronegativity of the beta-substituent on the ring. Beta-substituents with an electron-donating effect caused a negative shift in the one-electron oxidation and one-electron reduction potentials of the nitroxyl radicals. In a similar aspect, beta-substituents with an electron-withdrawing effect behaved oppositely. |
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