A Positron Emission Tomography Analysis of Glucose Metabolism in Alzheimer's Disease Brain Using [18F] Fluorodeoxyglucose: A Parallel Study with Elemental Concentrations |
| |
| Authors: | D A Cutts N M Spyrou R P Maguire J D Stedman K L Leenders |
| |
| Institution: | (1) Physics Department, University of Surrey, Guildford, Surrey, GU2 5XH, UK;(2) Physics Department, University of Surrey, Guildford, Surrey, GU2 5XH, UK;(3) Academic Hospital Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands;(4) Academic Hospital Groningen, Hanzeplein 1, NL-9700 RB Groningen, The Netherlands |
| |
| Abstract: | Alzheimer's disease (AD) is a debilitating form of dementia which leads to impaired memory, thinking and behavior. This work examines elemental concentrations between "normal" and AD subjects as well as the hemispherical differences within the brain. Tissue samples from both hemispheres of the frontal lobe in both AD and normal subjects were examined for their trace element concentrations using PIXE and RBS analyses. Elemental concentrations were seen to differ between AD and normal brain tissue samples. While in the normal group concentrations were found to be significantly higher in the right hemisphere than in the left the converse was true in AD. A change in elemental concentrations may indicate possible alterations in the function of the blood brain barrier. This was examined by determining regional cerebral metabolic rates of glucose (rCMRGlu) using the in vivo technique of positron emission tomography (PET). Again variations between both hemispheres and between AD and normal were found. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
